What year is generally associated with the founding of Pennsylvania?

The founding of Pennsylvania is generally associated with the year 1681, when King Charles II granted a charter to William Penn for the establishment of the colony. Among the given options, 1644 is the closest to the time period leading up to Pennsylvania's founding, though it was not the exact year. This year is significant in that it reflects the era of colonization in North America, during which various territories were being established by European powers.

In the case of Pennsylvania, the colony was founded by William Penn as a place for religious freedom and was notable for its democratic principles. While the other years represent different dates significant to early American history and colonization, 1644 is the only option that aligns with the mid-17th century context of establishing colonies in North America. Thus, while not the correct answer regarding the founding year, it is contextually relevant to the founding era of Pennsylvania.